Ir-catalyzed asymmetric hydrogenation of β-keto esters with chiral ferrocenyl P, N, N-ligands

被引：16
|
作者：
Chen, Xiu-Shuai [1 ,2 ]
Hou, Chuan-Jin [1 ,3 ]
Qin, Chao [1 ,2 ]
Liu, Hongzhu [3 ]
Liu, Yan-Jun [1 ]
Huang, De-Zhi [1 ]
Hu, Xiang-Ping [2 ]
机构：
[1] Dalian Polytech Univ, Sch Light Ind & Chem Engn, Dalian 116034, Peoples R China
[2] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China
[3] Dalian Zhenbang Fluorocarbon Paint Stock Co Ltd, Postdoctoral Res Stn, Dalian 116036, Peoples R China
来源：
RSC ADVANCES | 2017年 / 7卷 / 21期
基金：
中国国家自然科学基金;
关键词：
FORMAL 3+2 CYCLOADDITION; DECARBOXYLATIVE PROPARGYLIC ALKYLATION; ENANTIOSELECTIVE HYDROGENATION; DIPHOSPHINE LIGANDS; HIGHLY EFFICIENT; DIPYRIDYLPHOSPHINE LIGAND; ALLYLIC SUBSTITUTION; KINETIC RESOLUTION; IRIDIUM CATALYSTS; KETOESTERS;
D O I：
10.1039/c7ra00472a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The Ir-catalyzed asymmetric hydrogenation of beta-keto esters with chiral ferrocenyl P, N, N-ligands has been developed. Under the optimized conditions, a wide range of beta-keto esters were hydrogenated to afford the corresponding beta-hydroxy esters in good to excellent enantioselectivities (up to 95% ee).
引用
收藏
页码：12871 / 12875
页数：5
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