Neural stem cell quiescence comes to an un-sticky end

被引：0
|
作者：
Long, Katherine R. [1 ]
Ffrench-Constant, Charles [1 ]
机构：
[1] MRC Ctr Regenerat Med, Edinburgh EH16 4UU, Midlothian, Scotland
来源：
NATURE CELL BIOLOGY | 2014年 / 16卷 / 07期
基金：
英国生物技术与生命科学研究理事会;
关键词：
ADULT MAMMALIAN BRAIN; N-CADHERIN; NEUROGENESIS; ASTROCYTES; ZONE;
D O I：
10.1038/ncb3003
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cell-cell interactions, a key feature of the stem cell niche, regulate many aspects of stem cell behaviour. N-cadherin-mediated anchorage of neural stem cells within the adult neural niche maintains stem cell quiescence, and its release by the metalloproteinase MT5-MMP promotes neural stem cell activation.
引用
收藏
页码：625 / 627
页数：4
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