Redox-Neutral Atom-Economic Pd(0)-Catalyzed Dearomatization of β-Naphthols with Alkynes toward Naphthalenones

被引：27
|
作者：
Fang, Xinxin
Zeng, Yuye
Li, Qiuyu
Wu, Zijun
Yao, Hequan [1 ]
Lin, Aijun [1 ]
机构：
[1] China Pharmaceut Univ, SKLNM, Sch Pharm, Nanjing 210009, Jiangsu, Peoples R China
来源：
ORGANIC LETTERS | 2018年 / 20卷 / 09期
基金：
中国国家自然科学基金;
关键词：
CATALYZED ALLYLIC ALKYLATION; ASYMMETRIC DEAROMATIZATION; ENANTIOSELECTIVE DEAROMATIZATION; ARYLATIVE DEAROMATIZATION; C-C; ALLYLATION; 2-NAPHTHOLS; DERIVATIVES; ALCOHOLS; IRIDIUM;
D O I：
10.1021/acs.orglett.8b00662
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A dearomative coupling of beta-naphthols with alkynes via Pd hydride catalysis has been developed. This redox-neutral strategy provides a straightforward platform to access diverse naphthalenones bearing congested quarternary stereocenters with excellent atom and step economy since no leaving groups are needed to preinstall on the allylic reagents. The overall utility of this protocol is exemplified by broad functional group compatibility and gram-scale capacity.
引用
收藏
页码：2530 / 2533
页数：4
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