Methionine synthase reductase A66G polymorphism and leukemia risk: evidence from published studies

被引:18
|
作者
Fang, Dai-Hua [1 ]
Ji, Qiang [2 ]
Fan, Cong-Hai [3 ]
An, Qi [2 ]
Li, Juan [1 ]
机构
[1] Xuzhou Childrens Hosp, Cent Lab, Xuzhou 221006, Jiangsu, Peoples R China
[2] Xuzhou Childrens Hosp, Div Hematol, Xuzhou 221006, Jiangsu, Peoples R China
[3] Xuzhou Childrens Hosp, Div Anesthesiol, Xuzhou 221006, Jiangsu, Peoples R China
关键词
MTRR; polymorphism; leukemia; meta-analysis; ACUTE LYMPHOBLASTIC-LEUKEMIA; FOLATE-RELATED GENES; CHILDHOOD; CANCER; ADULTS; METAANALYSIS; PATHWAY;
D O I
10.3109/10428194.2013.867492
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Methionine synthase reductase (MTRR) is required for the reductive methylation of cobalamin, which is the functional cofactorial form of methionine synthase (MS) in the remethylation of homocysteine to methionine. The MTRR A66G (rs1801394) polymorphism is found to be associated with decreased enzyme affinity for MTR, the gene that encodes MS, and has been widely investigated for cancer risk, including leukemia. However, the conclusions of epidemiological studies have always been contradictory. To further clarify the association of MTRR A66G polymorphism with the risk of leukemia, this meta-analysis was performed for 2913 cases and 4764 controls. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Pooled ORs were determined for the co-dominant model (GG vs. AA, AG vs. AA), dominant model (GG + AG vs. AA) and recessive model (GG vs. AA + AG), respectively. No significant associations were found for all comparisons in the overall pooled analysis. However, the results of stratified analyses revealed that MTRR A66G GG genotype was associated with decreased leukemia risk in the Caucasian population, in children and for acute lymphoblastic leukemia (ALL). In contrast, increased risk was observed in the Asian population and for acute myeloid leukemia (AML). This meta-analysis suggests that MTRR A66G GG is associated with decreased risk of leukemia in a Caucasian population and in children, especially for ALL.
引用
收藏
页码:1910 / 1914
页数:5
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