Copper-Catalyzed Carboxamide-Directed Ortho Amination of Anilines with Alkylamines at Room Temperature

被引：179
|
作者：
Li, Qiong [1 ]
Zhang, Shu-Yu [1 ]
He, Gang [1 ]
Ai, Zhaoyan [1 ]
Nack, William A. [1 ]
Chen, Gong [1 ]
机构：
[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA
来源：
ORGANIC LETTERS | 2014年 / 16卷 / 06期
基金：
美国国家科学基金会;
关键词：
C-H BONDS; UNACTIVATED C(SP(3))-H; C(SP(2))-H BONDS; PALLADIUM; ARYLATION; FUNCTIONALIZATION; ALKOXYLATION; ALKYLATION; COMPLEXES; OXIDATION;
D O I：
10.1021/ol500464x
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In this report, a highly efficient method for the room temperature installation of alkyl amino motifs onto the ortho position of anilines via Cu-catalyzed carboxamide-directed amination with alkylamines is described. This method offers a practical solution for the rapid synthesis of complex arylamines from simple starting materials and enables new planning strategies for the construction of arylamine-containing pharmacophores. A single electron transfer (SET)-mediated mechanism is proposed.
引用
收藏
页码：1764 / 1767
页数：4
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