Clinical and Biological Relationship Between Chronic Lymphocytic Thyroiditis and Papillary Thyroid Carcinoma

被引：35
|
作者：
Antonaci, Alfredo [1 ]
Consorti, Fabrizio [1 ]
Mardente, Stefania [2 ]
Giovannone, Gloria [1 ]
机构：
[1] Univ Roma La Sapienza, Dept Surg Francesco Durante, I-00161 Rome, Italy
[2] Univ Roma La Sapienza, Dept Expt Med, I-00161 Rome, Italy
来源：
ONCOLOGY RESEARCH | 2009年 / 17卷 / 10期
关键词：
Chronic lymphocytic thyroiditis; Papillary thyroid carcinoma; Oncogenes; Apoptosis; HASHIMOTOS-THYROIDITIS; CYCLOOXYGENASE-2; EXPRESSION; RET/PTC REARRANGEMENTS; GENE-EXPRESSION; HIGH PREVALENCE; RET ACTIVATION; BRAF MUTATION; PCCL3; CELLS; CANCER; TUMORS;
D O I：
10.3727/096504009789735431
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The association between chronic lymphocytic thyroiditis and papillary thyroid carcinoma has been investigated for several years from different perspectives but with few attempts to design a common frame of reference to understand the complex mutual interactions between the various pathways of inflammatory response and of thyroid tumor induction and progression. This article reviews the current knowledge and research on this topic according to epidemiologic, immunobiologic, pathologic, and biomolecular points of view, highlighting achievements and lack of knowledge. It draws some conclusions and points at possible future directions for research.
引用
收藏
页码：495 / 503
页数：9
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