Synthesis, structure, and DNA cleavage activity of new trinuclear Zn3 and Zn2Cu complexes of a chiral macrocycle:: Structural correlation with the active center of P1 nuclease

被引：84

作者：

Korupoju, SR

Mangayarkarasi, N

Zacharias, PS ^{[1
]}

Mizuthani, J

Nishihara, H

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

[2] Univ Tokyo, Sch Sci, Dept Chem, Bunkyo Ku, Tokyo 1130033, Japan

来源：

INORGANIC CHEMISTRY | 2002年 / 41卷 / 16期

关键词：

D O I：

10.1021/ic0201102

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

New homo trinuclear Zn(II) complexes [Zn3L1(u-OAc)](ClO4)(2).3CHCl(3).H2O,1, and [Zn3L1(u-OAc)].ClO4.PF6.5CH(3)OH.H2O, 2, and hetero trinuclear complex [Zn2CuL1(mu-OAc)](ClO4)(2).3CHCl(3).H2O, 3, of optically active hexaaza triphenolic macrocycle H3L1 were synthesized and crystallographically characterized. The cation [Zn3L1(mu-OAc)](+) structure of 1 and 2 closely resembles the trinuclear Zn(II) active site of P1 nuclease. The distorted tetrahedral geometry of Zn3 was successfully reproduced at Cut in complex 3. The complexes 2 and 3 cleave CT DNA at 37 and 50 degreesC.

引用

页码：4099 / 4101

页数：3

共 7 条

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