Construction of a blood compatible coating via amphiphilic comb-like poly(ethylene glycol)

A water soluble hydroxy-capped comb-like poly (ethylene glycol) (CPEG) was prepared via atom transfer radical polymerization (ATRP). A stable CPEG coating was obtained via dip-coating followed by curing at 70 degrees C for 48 h. The CPEG-modified surface was proved to be stable in both aqueous environment and ambient according to contact angle behavior and weight decrement testing. The coating forming mechanism was investigated through FTIR,the spectra data demonstrated the stability of CPEG coating derived from its hydrogen bond of inter-molecules and intra-molecules. Platelet experiment showed CPEG modified surface reacted extremely weakly with platelet and showed excellent thrombus resistance than that of both on the pure PET surface and PET surface modified with linear PEG. The model drug RD6G was applied to fabricate a drug-buried CPEG coating surface. The drug-releasing curve demonstrated the stability of the CPEG coating and the controlled-release behavior of RD6G. The unique property of CPEG coating surface provided the potential application in the immobilization and release of aqueous drug,including protein and peptide.