Hydrothermal Synthesis of Cobalt- Doped Hydroxyapatite Nanopartieles: Structure, Magnetic Behaviour, Bioaetivity and Antibacterial Activity

This study. ocuses on the physical, magnetic, biological and antibacterial behavior of cobalt -doped hydroxyapatite (HAp) powder samples. Pure and cobalt-doped HAp nanoparticles were synthesized by hydrothermal method. Calcium nitrate, di-ammonium hydrogen phosphate and cobalt nitrate weir used as precursor ntaterials. The synthesized powders were characterized using x-ray diffraction pattern Pap), fowler transform infrared spectroscopy (FTIR), field lemission scanning election nzieroscopy (FESEM), vibrating sample magnetometer (VSM), raman spectroscopy as well as MITT assay and cell adhesion test Disc diffusion method was used to investigate antibacterial activity of the samples. The results confirmed the substitution of Ca by Co ions in the HAp lattice. In addition, this substitution induced size reduction and morphology change in HAp particles. All cobalt substituted HAp powder samples displayed paramagnetic properties, as opposed to the diamagnetic behavior observed in the pure HAp samples. In addition, these nanoparticles exhibited cell adhesion, cell viability and antibacterial activity against S.aureus bacteria.