Nitric oxide mediates NMDA-evoked [H-3]GABA release from chick retina cells

被引:19
|
作者
Ientile, R
Pedale, S
Picciurro, V
Macaione, V
Fabiano, C
Macaione, S
机构
[1] Inst. Biochem. Sci. Clin. Biochem., Fac. Med., Univ. Messina, Viale I.
关键词
nitric oxide; chick embryo; retina cell; NMDA; GABA release;
D O I
10.1016/S0014-5793(97)01322-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The stimulation of NMDA receptor increased [H-3]GABA release from preloaded cultured retina cells. This effect appears to be mediated by NO production, since addition of L-NA reduces NMDA-evoked [H-3]GABA release. Spermine/ NO complex, an NO donor, mimics the effect produced by NMDA, The addition of zaprinast, a phosphodiesterase inhibitor, as well as 8-Br-cGMP enhances the NMDA-evoked [H-3]GABA release. These results agree with the existence in chick retina cells of NO/cGMP pathways and support a role for NO in NMDA-evoked events, The activation of this receptor complex through maturative stages of the retina together with the NO-mediated increase in GABA release may account for NMDA differentiative effect in culturing retina cells. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码:345 / 348
页数:4
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