Association of angiotensin receptor 2 gene polymorphisms with pregnancy induced hypertension risk

被引：9
|
作者：
Li, Chenyang [1 ]
Peng, Weijun [1 ,2 ]
Zhang, Heng [1 ,3 ]
Yan, Weirong [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Epidemiol & Biostat, Wuhan, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Hosp Infect Management, Wuhan, Hubei, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Neurol, Wuhan, Hubei, Peoples R China
来源：
HYPERTENSION IN PREGNANCY | 2018年 / 37卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Angiotensin receptor 2; pregnancy induced hypertension; single nucleotide polymorphisms; haplotype analysis; BLOOD-PRESSURE; II TYPE-1; PREECLAMPSIA; AGTR2; POPULATION; EXPRESSION; DISORDERS;
D O I：
10.1080/10641955.2018.1460666
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objectives: To investigate the association of polymorphisms and haplotypes of angiotensin receptor 2 (AT2R) gene with pregnancy induced hypertension (PIH) in Chinese Han women. Methods: A case-control study was designed with 446 cases (gestational hypertension, GH: 124; pre-eclampsia, PE + eclampsia, E: 322) and 650 controls. rs5193, rs1403543 and rs12710567 of AT2R gene were genotyped. A logistic regression approach was applied to estimate the relationship between the polymorphisms and haplotypes of AT2Rgene with PIH risk. Results: No relationship between AT2R gene polymorphisms and PIH was detected. The haplotype analysis also showed a negative result. Conclusions: rs5193, rs1403543 and rs12710567 of AT2R gene might have no effect on PIH risk among Chinese Han women.
引用
收藏
页码：87 / 92
页数：6
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