Identification of prognostic chromatin-remodeling genes in clear cell renal cell carcinoma

被引:0
|
作者
Yang, Yujing [1 ]
Wang, Chengyuan [2 ]
Wei, Ningde [2 ]
Hong, Ting [2 ]
Sun, Zuyu [2 ]
Xiao, Jiawen [3 ]
Yao, Jiaxi [2 ]
Li, Zhi [1 ]
Liu, Tao [2 ]
机构
[1] China Med Univ, Affiliated Hosp 1, Dept Med Oncol, Shenyang 110001, Peoples R China
[2] China Med Univ, Affiliated Hosp 1, Dept Urol, Shenyang 110001, Peoples R China
[3] Shenyang Fifth People Hosp, Dept Med Oncol, Shenyang 110001, Peoples R China
来源
AGING-US | 2020年 / 12卷 / 24期
基金
中国国家自然科学基金;
关键词
clear cell renal cell carcinoma (ccRCC); chromatin-remodeling genes; prognostic biomarkers; BPTF; SIN3A; TRANSCRIPTION FACTOR; DEACETYLASE COMPLEX; PHD-FINGER; BPTF; SURVIVAL; PROTEIN; GROWTH; YY1; ACTIVATION; PHENOTYPE;
D O I
暂无
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The aim of this study was to investigate the effects of chromatin-remodeling genes on the prognosis of patients with clear cell renal cell carcinoma (ccRCC). In TCGA-KIRC patients, two subgroups based on 86 chromatin-remodeling genes were established. The random forest algorithm was used for feature selection to identify BPTF, SIN3A and CNOT1 as characterized chromatin remodelers in ccRCC with good prognostic value. YY1 was indicated to be a transcription factor of genes highly related to BPTF, SIN3A and CNOT1. Functional annotations indicated that BPTF, SIN3A, CNOT1 and YY1 are all involved in the ubiquitin-mediated proteolysis process and that high expression of any of the five associated E3 ubiquitin ligases found in the pathway suggests a goodprognosis. Protein network analysis indicated that BPTF has a targeted regulatory effect on YY1. Another independent dataset from International Cancer Genome Consortium (ICGC) showed a strong consistency with results in TCGA. In conclusion, we demonstrate that BPTF, SIN3A and CNOT1 are novel prognostic factors that predict good survival in ccRCC. We predicted that the good prognostic value of chromatin-remodeling genes BPTF and SIN3A is related to the regulation of YY1 and that YY1 regulates E3 ubiquitin ligases for further degradation of oncoproteins in ccRCC.
引用
收藏
页码:25614 / 25642
页数:29
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