Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

被引：2
|
作者：
Lei, Qijing [1 ]
Pan, Qin [1 ]
Yu, Shuai [1 ]
Li, Na [1 ]
Chen, Shulin [1 ]
Sidhu, Kuldip [2 ]
Hua, Jinlian [1 ]
机构：
[1] Northwest A&F Univ, Coll Vet Med, Shaanxi Ctr Stem Cells Engn & Technol, Yangling 712100, Shaanxi, Peoples R China
[2] UNSW Med, Ctr Hlth Brain Ageing, Randwick, NSW 2031, Australia
来源：
FRONTIERS OF AGRICULTURAL SCIENCE AND ENGINEERING | 2019年 / 6卷 / 01期
基金：
中国国家自然科学基金;
关键词：
pig; pluripotent stem cells; primordial germ cells; reprogramming; IN-VITRO; FIBROBLASTS; GENERATION; EXPRESSION; ESTABLISHMENT; DERIVATION; INDUCTION; LINEAGE; NANOG; OCT4;
D O I：
10.15302/J-FASE-2018222
中图分类号：
S3 [农学（农艺学）];
学科分类号：
0901 ;
摘要：
Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogonia or oocytes. However, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cells and then by reprogramming to induce them to become pluripotent stem cells (iPSCs). These two stages can be completely implemented with mouse cells. However, authentic porcine iPSCs have not been established. Here, we discuss recent advances in the stem cell field for obtaining iPSCs from PGCs. This knowledge will provide some clues which will contribute to the regulation of reprogramming to pluripotency in farm species.
引用
收藏
页码：28 / 32
页数：5
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