Acute and subacute toxicity study of 1,8-cineole in mice

被引：0

作者：

Xu, Jiao ^{[1
,4
]}

Hu, Zhi-Qiang ^{[1
]}

Wang, Chuan ^{[1
]}

Yin, Zhong-Qiong ^{[1
]}

Wei, Qin ^{[2
]}

Zhou, Li-Jun ^{[1
]}

Li, Li ^{[1
]}

Du, Yong-Hua ^{[2
]}

Jia, Ren-Yong ^{[1
]}

Li, Mei ^{[3
]}

Fan, Qiao-Jia ^{[1
]}

Liang, Xiao-Xia ^{[1
]}

He, Chang-Liang ^{[1
]}

Yin, Li-Zi ^{[1
]}

机构：

[1] Sichuan Agr Univ, Coll Vet Med, Yaan 625014, Sichuan, Peoples R China

[2] Yibin Coll, Key Lab Southwest Special Econ Plant Protect & Ut, Yibin 644000, Peoples R China

[3] Sichuan Agricutural Univ, Coll Forestry, Yaan 625014, Peoples R China

[4] Leshan Vocat & Tech Coll, Leshan 614000, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2014年 / 7卷 / 04期

基金：

中国国家自然科学基金;

关键词：

1,8-cineole; toxicity; histopathology; ultrastructural changes; mice; ESSENTIAL OIL; EUCALYPTUS; RATS;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The effects of acute and subacute toxicity of 1,8-cineole in Kunming mice were studied. After acute oral administration, the LD50 value (95% CL) was 3849 mg/kg (3488.8 similar to 4247.1 mg/kg). In the subacute toxicity study, there were no significant differences in body weight and relative organ weight between the control group and 1,8-cineole treatment groups. The histopathological examinations showed that granular degeneration and vacuolar degeneration appeared in liver and kidney tissue after administration of high dose of 1,8-cineole. Under electron microscopy, a series of ultrastructural changes were observed: The electron microscopy assays indicated that the influence of 1,8-cineole on the target organ at the subcellular level were mainly on the mitochondria, endoplasmic reticulum and other membrane type structure of liver and kidney.

引用

页码：1495 / 1501

页数：7

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