Age-related changes in plasma lipid peroxidation and antioxidant system in humans and rats

被引：9
|
作者：
Mehmetcik, G
Ozdemirler, G
Kanbagli, O
Toker, G
Uysal, M
机构：
[1] UNIV ISTANBUL, ISTANBUL FAC MED, DEPT BIOCHEM, TR-34390 CAPA, ISTANBUL, TURKEY
[2] NEAR EAST UNIV, ART & SCI FAC, LEFKOSA, TURKEY
来源：
ARCHIVES OF GERONTOLOGY AND GERIATRICS | 1997年 / 25卷 / 03期
关键词：
aging; plasma; lipid peroxidation; antioxidant system; Apo-B containing lipoproteins;
D O I：
10.1016/S0167-4943(97)00023-X
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
This study was carried out on young (20-35 years) and old (60-85 years) men and rats (6 vs 22 months) to investigate the effect of aging on plasma lipid peroxidation and the antioxidant system. Plasma polyunsaturated fatty acid (PUFA), total fatty acid (TFA) and malondialdehyde (MDA) levels increased in aged humans and rats compared with young groups. However, plasma MDA/TFA ratios did not increase in aged humans and rats. Plasma vitamin E/TFA, and total thiol content were found to decrease both in aged humans and rats. Plasma antioxidant activity (AOA) decreased only in aged rats. In addition, the susceptibility of VLDL + LDL, apolipoprotein B containing lipoproteins to copper-induced peroxidation increased with aging. It is concluded that aging is associated with some variations in plasma oxidant-antioxidant balance. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：305 / 310
页数：6
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