Genetic susceptibility to nicotine and/or alcohol addiction: a systematic review

被引：5
|
作者：
Legaz, Isabel [1 ]
Perez-Carceles, M. D. [2 ]
de la Calle, Irene [1 ]
Arjona, Fuensanta [1 ]
Roca, Miriam [1 ]
Cejudo, Pablo [1 ]
Luna, Aurelio [1 ]
Osuna, Eduardo [1 ]
机构：
[1] Univ Murcia, Espinardo Campus, Murcia, Spain
[2] Univ Murcia, Fac Med, Dept Legal & Forens Med, Biomed Res Inst IMIB, Reg Campus Int Excellence Campus Mare Nostrum, Murcia, Spain
来源：
TOXIN REVIEWS | 2021年 / 40卷 / 04期
关键词：
Alcohol; addiction; human clinical toxicology; nicotine; genetic susceptibility; GENOME-WIDE ASSOCIATION; ANGIOTENSIN-CONVERTING ENZYME; INSERTION/DELETION POLYMORPHISM; SEROTONIN TRANSPORTER; TOBACCO DEPENDENCE; AFRICAN-AMERICANS; DOPAMINE RELEASE; RECEPTORS; CYP2A6; VARIANTS;
D O I：
10.1080/15569543.2019.1619085
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
Recent studies have confirmed the wide consumption of tobacco and alcohol in our society and the strong addiction generated by these substances, which is responsible for high public health expenditure. Understanding the biological mechanisms of nicotine and/or alcohol dependence should have huge public health repercussions in the future. The aim of this review was to analyze the main human genes and polymorphisms related to nicotine and/or alcohol addiction, to help understand the biological mechanisms involved and which may be useful for developing new treatments in the future.
引用
收藏
页码：371 / 382
页数：12
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