Bronsted acid-catalyzed Mannich-type reactions in aqueous media

被引：0
|
作者：
Akiyama, T [1 ]
Takaya, J [1 ]
Kagoshima, H [1 ]
机构：
[1] Gakushuin Univ, Fac Sci, Dept Chem, Toshima Ku, Tokyo 1718588, Japan
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2002年 / 344卷 / 3-4期
关键词：
aldimine; Bronsted acid; Mannich-type reaction; water as solvent;
D O I：
10.1002/1615-4169(200206)344:3/4<338::AID-ADSC338>3.0.CO;2-O
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
HBF4-catalyzed Mannich-type reaction of silyl enolates with aldimines took place smoothly in aqueous organic solvent to afford beta-aminocarbonyl compounds in high yields. The HBF4-catalyzed Mannich-type reaction also proceeded smoothly in water without organic solvent in the presence of a surfactant. A three-component synthesis starting from aldehyde, amine, and silyl enolate was successfully realized by means of a Bronsted acid in aqueous media.
引用
收藏
页码：338 / 347
页数：10
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