Optimization of fermentation medium by a modified method of genetic algorithms

被引:20
|
作者
Zuzek, M [1 ]
Friedrich, J [1 ]
Cestnik, B [1 ]
Karalic, A [1 ]
Cimerman, A [1 ]
机构
[1] JOZEF STEFAN INST,LJUBLJANA 1000,SLOVENIA
关键词
D O I
10.1007/BF00180409
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
During the study of mevinolin biosynthesis by Aspergillus terreus ATCC 20542, 10 different medium components were selected for medium optimization. A new optimization method based on genetic algorithms and inductive learning was used for experimental design. For better efficiency the method was supported by a model, constructed with machine learning method, to predict the productivity. In four generations of fermentation experiments the productivity increased nearly three times.
引用
收藏
页码:991 / 996
页数:6
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