Design and synthesis of a deep tissue penetrating near-infrared two-photon fluorescence probe for the specific detection of NQO1

被引：8
|
作者：
Wu, Wenjing [1 ,2 ]
Li, Xing [1 ,2 ]
Zhao, Lingyu [1 ,2 ]
Li, Shumu [1 ]
Han, Juanjuan [1 ]
Zhang, Yangyang [1 ,2 ]
Zhao, Zhenwen [1 ,2 ]
机构：
[1] Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, CAS Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 37期
基金：
中国国家自然科学基金; 国家重点研发计划;
关键词：
D O I：
10.1039/d2cc01654k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
NAD(P)H:quinone oxidoreductase 1 (NQO1) is overexpressed in a broad range of human tumors but remains difficult to study. Herein, we report a novel two-photon fluorescent probe with NIR emission for NQO1 detection. The probe demonstrated superior analytical performance with a large Stokes shift and deep tissue penetration.
引用
收藏
页码：5634 / 5637
页数：4
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