Osteonecrosis of the jaw in patient with denosumab therapy

被引：0

作者：

Olate, Sergio ^{[1
,2
,3
]}

Uribe, Francisca ^{[1
,2
,4
]}

Martinez, Felipe ^{[1
,2
]}

Almeida, Andres ^{[1
,2
]}

Unibazo, Alejandro ^{[1
,2
,5
]}

机构：

[1] Univ La Frontera, Div Oral & Maxillofacial Surg, Temuco, Chile

[2] Univ La Frontera, CIMA Grp, Temuco, Chile

[3] Univ Autonoma Chile, Ctr Biomed Res, Santiago, Chile

[4] Univ La Frontera, Programa Doctorado Ciencias Med, Temuco, Chile

[5] Univ La Frontera, Programa Magister Ciencias Odontol, Temuco, Chile

来源：

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2014年 / 7卷 / 10期

关键词：

Denosumab; osteonecrosis; cancer therapy;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Osteonecrosis (ON) of the jaw has previously been linked to the use of biphosphonates; however, new drugs, also shown similar conditions. This article presents a female patient with mandibular ON related to the use of denosumab. The 55-year-old presented with bone exposure with 8 months of evolution after a dental extraction. The patient began subcutaneous injections of 60 mg denosumab four months prior to the extraction and the lesion remained after the procedure. The patient, with 14 months of follow-up, show mandible ON with no favorable evolution. The clinical condition is presented and the literature of ON associated with denosumab is discussed.

引用

页码：3707 / 3709

页数：3

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