Membrane Biogenesis: Networking at the ER with Atlastin

被引:13
|
作者
Farhan, Hesso [1 ]
Hauri, Hans-Peter [1 ]
机构
[1] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland
关键词
HEREDITARY SPASTIC PARAPLEGIA; ENDOPLASMIC-RETICULUM; DYNAMIN; MICROTUBULES; FUSION; MORPHOGENESIS; GTPASES; GOLGI;
D O I
10.1016/j.cub.2009.08.029
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The peripheral endoplasmic reticulum forms a dynamic network of interconnected membrane tubules. Although some determinants of this striking architecture are known, the mechanism underlying fusion of individual tubules has remained elusive. Two studies now identify atlastin proteins as key mediators of homotypic fusion of endoplasmic reticulum membranes.
引用
收藏
页码:R906 / R908
页数:3
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