Spontaneous and genetically engineered animal models: use in preclinical cancer drug development

被引：155
|
作者：
Hansen, K [1 ]
Khanna, C [1 ]
机构：
[1] NCI, Canc Res Ctr, Comparat Oncol Program, NIH, Rockville, MD USA
来源：
EUROPEAN JOURNAL OF CANCER | 2004年 / 40卷 / 06期
关键词：
cancers; GEM; mouse; transgenic; canine comparative; spontaneous;
D O I：
10.1016/j.ejca.2003.11.031
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The preclinical development of anticancer drugs has been based primarily on the transplantation of murine or human cancers into mice. Alternatives to these transplantation models are animals that naturally develop cancers with features relevant to the human disease. The first group of these models arises in mice that are genetically engineered to develop cancer. The second group includes pet dogs and cats that naturally develop cancer. This review will discuss the use and integration of these spontaneous cancer models into a comprehensive and comparative approach to preclinical drug development. Examples of their successful use and an outline of their relative strengths and weaknesses will be provided. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：858 / 880
页数：23
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