Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents

被引：85
|
作者：
Rathore, Bhawani Singh [1 ]
Kumar, M. [1 ]
机构：
[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 16期
关键词：
4H-1,4-benzothiazines; beta-diketone/beta-ketoesters; 2-aminobenzenethiols;
D O I：
10.1016/j.bmc.2006.04.009
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
7-Chloro-5-trifluoromethy1/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/beta-ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5678 / 5682
页数：5
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