Treatment of idiopathic oligozoospermia with recombinant human follicle-stimulating hormone: a prospective, randomized, double-blind, placebo-controlled clinical study in Chinese population

被引:48
|
作者
Ding, Yin-man [1 ]
Zhang, Xin-ji [2 ]
Li, Jing-Ping [3 ]
Chen, San-san [4 ]
Zhang, Ren-tao [1 ]
Tan, Wan-long [4 ]
Shi, Xiao-Jun [1 ]
机构
[1] Peoples Hosp Xuancheng City, Dept Urol, Xuancheng 242000, Anhui, Peoples R China
[2] Southern Med Univ, Shunde Peoples Hosp 1, Dept Urol, Guangzhou, Guangdong, Peoples R China
[3] Zhejiang Univ, Sch Med, Womens Hosp, Dept Reprod Endocrinol, Hangzhou 310003, Zhejiang, Peoples R China
[4] Southern Med Univ, Nanfang Hosp, Dept Urol, Guangzhou, Guangdong, Peoples R China
关键词
MALE-FACTOR INFERTILITY; INHIBIN-B; SPERMATOGENESIS; MEN; FSH; GONADOTROPIN; QUALITY; TRIAL; MALES;
D O I
10.1111/cen.12770
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective Follicle-stimulating hormone plays a crucial role in spermatogenesis. The aim of this study was to evaluate the efficacy of treatment with FSH in Chinese infertility population. Design Prospective, randomized, double-blind, placebo-controlled clinical study. Patients A total of 354 men affected by idiopathic oligozoospermia from three medical centres. Measurements This study contained three parts: (i) treatment with different doses of rhFSH (50 IU, 100 IU, 200 IU and 300 IU); (ii) the efficacy of rhFSH at different periods (2, 3, 4, 5 months); (iii) FSH treatment in patients with different levels of inhibin B (normal-level group, low-level group and high-level group). Semen parameters were evaluated in all subjects. The patients who had not reached spontaneous pregnancy underwent assisted reproductive techniques. Results Sperm number was significantly increased after treatment with FSH at doses of at least 200 IU, and the improvement was observed beginning at the third month. The significant improvement in both morphology and forward motility was observed beginning at the fifth month. Moreover, 300 IU rhFSH administration for 5 months could significantly improve the spontaneous pregnancy rate (12/40) and ART pregnancy rate (14/28), while the rates for placebo group were two of twenty-nine and five of twenty-seven, respectively. The seminal parameters (total sperm count, sperm concentration, forward motility and morphology) were significantly improved in the normal-and low-level inhibin B groups, but no significant variation was observed in the high-level group at the end of the study. Conclusions The efficacy of FSH treatment was associated with the dose of FSH and duration of treatment, and FSH therapy was more effective in patients with normal level and low level of inhibin B.
引用
收藏
页码:866 / 871
页数:6
相关论文
共 50 条
  • [1] Recombinant human follicle stimulating hormone for treatment of male idiopathic infertility:: a randomized, double-blind, placebo-controlled, clinical trial
    Kamischke, A
    Behre, HM
    Bergmann, M
    Simoni, M
    Schäfer, T
    Nieschlag, E
    HUMAN REPRODUCTION, 1998, 13 (03) : 596 - 603
  • [2] Treatment of male idiopathic infertility with recombinant human follicle-stimulating hormone: a prospective, controlled, randomized clinical study
    Foresta, C
    Bettella, A
    Garolla, A
    Ambrosini, G
    Ferlin, A
    FERTILITY AND STERILITY, 2005, 84 (03) : 654 - 661
  • [3] Treatment of idiopathic oligozoospermia with an alpha-blocker: A placebo-controlled double-blind trial
    Gregoriou, O
    Vitoratos, N
    Papadias, C
    Gargaropoulos, A
    Konidaris, S
    Giannopoulos, V
    Chryssicopoulos, A
    INTERNATIONAL JOURNAL OF FERTILITY AND WOMENS MEDICINE, 1997, 42 (05): : 301 - 305
  • [4] Liposomal recombinant human superoxide dismutase for the treatment of Peyronie's disease:: A randomized placebo-controlled double-blind prospective clinical study
    Riedl, CR
    Sternig, P
    Gallé, G
    Langmann, F
    Vcelar, B
    Vorauer, K
    Wagner, A
    Katinger, H
    Pflüger, H
    EUROPEAN UROLOGY, 2005, 48 (04) : 656 - 661
  • [5] A randomized, double-blind, placebo-controlled study of growth hormone in the treatment of fibromyalgia
    Bennett, RM
    Clark, SC
    Walczyk, J
    AMERICAN JOURNAL OF MEDICINE, 1998, 104 (03): : 227 - 231
  • [6] EFFECT OF HUMAN CHORIONIC-GONADOTROPIN (HCG)/FOLLICLE-STIMULATING HORMONE-TREATMENT VERSUS HCG TREATMENT ALONE ON TESTICULAR DESCENT - A DOUBLE-BLIND PLACEBO-CONTROLLED STUDY
    HOORWEGNIJMAN, JJG
    HAVERS, HM
    DELEMARREVANDEWAAL, HA
    EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1994, 130 (01) : 60 - 64
  • [7] Recombinant human relaxin in the treatment of scleroderma - A randomized, double-blind, placebo-controlled trial
    Seibold, JR
    Korn, JH
    Simms, R
    Clements, PJ
    Moreland, LW
    Mayes, MD
    Furst, DE
    Rothfield, N
    Steen, V
    Weisman, M
    Collier, D
    Wigley, FM
    Merkel, PA
    Csuka, ME
    Hsu, V
    Rocco, S
    Erikson, M
    Hannigan, J
    Harkonen, WS
    Sanders, ME
    ANNALS OF INTERNAL MEDICINE, 2000, 132 (11) : 871 - +
  • [8] Levocetirizine in the treatment of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study
    Nettis, E
    Colanardi, MC
    Barra, L
    Ferrannini, A
    Vacca, A
    Tursi, A
    BRITISH JOURNAL OF DERMATOLOGY, 2006, 154 (03) : 533 - 538
  • [9] A randomized double-blind, placebo-controlled study of omalizumab for idiopathic anaphylaxis
    Carter, Melody C.
    Maric, Irina
    Brittain, Erica H.
    Bai, Yun
    Lumbard, Keith
    Bolan, Hyejeong
    Cantave, Daly
    Scott, Linda M.
    Metcalfe, Dean D.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2021, 147 (03) : 1004 - +
  • [10] Growth hormone treatment in hemodialysis patients - A randomized, double-blind, placebo-controlled study
    Ericsson, F
    Divino, JC
    Lindgren, BF
    SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY, 2004, 38 (04): : 340 - 347