A New Xanthone from the Fermentation Products of Endophytic Fungus of Phomopsis Species

被引：3
|
作者：
Yang, Yuchun [1 ,2 ]
Yang, Haiyin [1 ,2 ]
Li, Yinke [1 ,2 ,3 ]
Ye, Yanqing [1 ,2 ]
Hu, Qiufen [1 ,2 ]
Gao, Xuemei [1 ,2 ]
Du, Gang [1 ,2 ]
机构：
[1] Yunnan Univ Nationalities, Key Lab Chem Ethn Med Resources, State Ethn Affairs Commiss, Kunming 650031, Peoples R China
[2] Yunnan Univ Nationalities, Minist Educ, Kunming 650031, Peoples R China
[3] Yuxi Normal Univ, Collge Resource & Environm, Yuxi 653100, Peoples R China
来源：
ASIAN JOURNAL OF CHEMISTRY | 2014年 / 26卷 / 15期
基金：
中国国家自然科学基金;
关键词：
Xanthone; Fermentation; Phomopsis; Endophytic; METABOLITES;
D O I：
10.14233/ajchem.2014.16127
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new xanthone, 1,3-dihydroxy-4-(1,3,4-trihydroxybutan-2-yl)-8-methoxy-9H-xanthen-9-one (1) was isolated from the fermentation products of a Phomopsis fungus. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D-NMR techniques. Compound 1 was also evaluated for their cytotoxicity against five human tumor cell lines and it showed high cytotoxicity against A549 and PC3 cell with IC50 values of 5.8 and 3.6 mu M, respectively.
引用
收藏
页码：4591 / 4593
页数：3
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