Correlation between SFRP1 expression and clinicopathological parameters in patients with triple-negative breast cancer

被引：12
|
作者：
Schaefer, Sarah Alexandra [1 ]
Huelsewig, Carolin [2 ]
Barth, Peter [3 ]
von Wahlde, Marie-Kristin [4 ]
Tio, Joke [4 ]
Kolberg, Hans-Christian [5 ]
Bernemann, Christof [6 ]
Blohmer, Jens-Uwe [7 ,8 ]
Kiesel, Ludwig [4 ]
Kolberg-Liedtke, Cornelia [7 ,8 ]
机构：
[1] Sana Kliniken Duisburg, Dept Pediat, Rehwiesen 9, D-47055 Duisburg, Germany
[2] Mol Hlth GmbH, Kurfurstenanlage 21, D-69115 Heidelberg, Germany
[3] Univ Munster, Gerhard Domagk Dept Pathol, Albert Schweitzer Campus 1 D17, D-48149 Munster, Germany
[4] Univ Hosp Munster, Dept Gynecol & Obstet, Albert Schweitzer Campus 1 A1, D-48149 Munster, Germany
[5] Marienhosp Bottrop, Dept Gynecol & Obstet, Josef Albers Str 70, D-46236 Bottrop, Germany
[6] Univ Munster, Dept Urol, Univ Hosp Munster, Fac Med, Albert Schweitzer Campus 1 A1,Domagkstr, D-48149 Munster, Germany
[7] Charite, Dept Gynecol, Charitepl 1, D-10117 Berlin, Germany
[8] Charite, Breast Ctr, Charitepl 1, D-10117 Berlin, Germany
来源：
FUTURE ONCOLOGY | 2019年 / 15卷 / 16期
关键词：
biomarker; chemotherapy; SFRP1; tissue microarray; triple-negative breast cancer; BASAL-LIKE; NEOADJUVANT THERAPY; TUMOR-SUPPRESSOR; METHYLATION; PROGNOSIS; GENE; CHEMOTHERAPY; SURVIVAL; SUBTYPES; PATHWAY;
D O I：
10.2217/fon-2018-0564
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Aim: Breast cancer is a heterogeneous disease with distinct molecular and clinical behavior demanding reliable biomarkers, especially in triple-negative breast cancer (TNBC). This study seeks to improve the understanding of SFRP1 as a potential biomarker in breast cancer focusing on TNBC. Materials & methods: SFRP1 expression was investigated via immunohistochemistry with two anti-SFRP1-antibodies on tissue-microarrays of 376 invasive breast cancers. Results: Statistical analysis revealed a highly significant association between TNBC (n=36) and SFRP1 expression (p<0.001). SFRP1 expression was significantly associated with younger age, higher tumor stage, size and grade. Conclusion: SFRP1 expression is strongly correlated with TNBC on protein level. Associations with age and tumor grade support the role of SFRP1 as a biomarker for chemotherapy response in TNBC.
引用
收藏
页码：1921 / 1938
页数：18
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