PRACTICAL AND FACILE ROUTE TO A FUNCTIONAL INTERMEDIATE FROM STIGMASTEROL FOR THE SYNTHESIS OF 1α-HYDROXYVITAMIN D5 AND RELATED COMPOUNDS

被引：1

作者：

Takahashi, Michiyasu ^{[1
]}

Hosokawa, Seiya ^{[1
]}

Ono, Yuuya ^{[1
]}

Kubodera, Noboru ^{[2
]}

机构：

[1] Ichinoseki Coll, Natl Inst Technol, Dept Chem Engn, Ichinoseki, Iwate 0218511, Japan

[2] Int Inst Act Vitamin D Analogs, 35-6 Sankeidai, Mishima, Shizuoka 4110017, Japan

来源：

HETEROCYCLES | 2016年 / 93卷 / 01期

关键词：

1 alpha-Hydroxyvitamin D-5; 1,2 alpha -Epoxide; Vitamin D-5; Stigmasterol; Vitamin D; VITAMIN-D ANALOGS; ALFACALCIDOL; PREVENTION;

D O I：

10.3987/COM-15-S(T)6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As a functional and versatile intermediate for the synthesis of la-hydroxyvitamin D-5 and related compounds, 1 alpha,2 alpha-epoxy-3 beta-hydroxystigmasta-5,7-diene was synthesized by a practical and facile 17-step route from stigmasterol in 17% overall yield.

引用

页码：101 / 113

页数：13

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