Adoptive cell therapy: past, present and future

被引：30
|
作者：
Cohen, Jonathan E. [1 ]
Merims, Sharon [1 ]
Frank, Stephen [1 ]
Engelstein, Roni [1 ]
Peretz, Tamar [1 ]
Lotem, Michal [1 ]
机构：
[1] Hadassah Hebrew Univ, Med Ctr, Sharett Inst Oncol, Jerusalem, Israel
来源：
IMMUNOTHERAPY | 2017年 / 9卷 / 02期
基金：
以色列科学基金会;
关键词：
adoptive cell therapy; cancer immunotherapy; tumor-infiltrating lymphocytes; TUMOR-INFILTRATING LYMPHOCYTES; CHIMERIC ANTIGEN RECEPTOR; CD8(+) T-CELLS; DOSE RECOMBINANT INTERLEUKIN-2; METASTATIC MELANOMA PATIENTS; TERM SURVIVAL UPDATE; TCR GENE-THERAPY; CANCER REGRESSION; B-CELL; TRANSFER IMMUNOTHERAPY;
D O I：
10.2217/imt-2016-0112
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The immune system is a potent inhibitor of tumor growth with curative potential, constituting in many eyes the future of antineoplastic therapy. Adoptive cell therapy (ACT) is a form of immunotherapy in which autologous cancer-cognate lymphocytes are expanded and modified ex vivo and re-infused to combat the tumor. This review follows the evolvement of ACT and treatment protocols, focusing on unresolved dilemmas regarding this treatment while providing evidence for its effectiveness in refractory patients. Future directions of ACT are discussed, in particular with regard to genetic engineering of autologous cells, and the role of ACT in the era of checkpoint inhibitors is addressed.
引用
收藏
页码：183 / 196
页数：14
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