Short- and Long-Term Effects of UV Radiation on the Pigmentation of Human Skin

被引：42

作者：

Coelho, Sergio G. ^{[1
]}

Choi, Wonseon ^{[1
]}

Brenner, Michaela ^{[1
]}

Miyamura, Yoshinori ^{[1
]}

Yamaguchi, Yuji ^{[1
]}

Wolber, Rainer ^{[2
]}

Smuda, Christoph ^{[2
]}

Batzer, Jan ^{[2
]}

Kolbe, Ludger ^{[2
]}

Ito, Shosuke ^{[3
]}

Wakamatsu, Kazumasa ^{[3
]}

Zmudzka, Barbara Z. ^{[4
]}

Beer, Janusz Z. ^{[4
]}

Miller, Sharon A. ^{[4
]}

Hearing, Vincent J. ^{[1
]}

机构：

[1] NCI, Pigment Cell Biol Sect, Cell Biol Lab, NIH, Bethesda, MD 20892 USA

[2] Beiersdorf AG, R&D Skin Res, Hamburg, Germany

[3] Fujita Hlth Univ, Sch Hlth Sci, Dept Chem, Aichi, Japan

[4] US FDA, Ctr Devices & Radiol Hlth, Silver Spring, MD USA

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS | 2009年 / 14卷 / 01期

关键词：

ULTRAVIOLET-RADIATION; MELANIN PIGMENTATION; DNA-DAMAGE; MECHANISMS; IRRADIATION; APOPTOSIS; RESPONSES; EPIDERMIS; CANCER;

D O I：

10.1038/jidsymp.2009.10

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The incidence of skin cancer, including cutaneous melanoma, has risen substantially in recent years, and epidemiological and laboratory studies show that UV radiation is a major causative factor of this increase. UV damage also underlies photoaging of the skin, and these deleterious effects of UV can be, in part, prevented in skin with higher levels of constitutive pigmentation. We review the clinical studies we have made in recent years regarding the rapid and the long-term responses of the pigmentary system in human skin to UV exposure.

引用

页码：32 / 35

页数：4

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