Age-specific spectrum of etiological pathogens for viral diarrhea among children in twelve consecutive winter-spring seasons (2009-2021) in China

被引：18

作者：

Wang, Gang ^{[1
]}

Zhao, Rui-Qiu ^{[2
]}

Tang, Xiang ^{[2
]}

Ren, Luo ^{[2
]}

Zhang, Yun-Fa ^{[1
]}

Ding, Heng ^{[1
]}

Li, Yue ^{[1
]}

Wang, Yu-Na ^{[1
]}

Li, Shuang ^{[1
]}

Zhang, Ling Yu ^{[1
]}

Liu, En-Mei ^{[2
]}

Xu, Hong-Mei ^{[2
]}

Zhang, Xiao-Ai ^{[1
]}

Liu, Wei ^{[1
,3
]}

机构：

[1] Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China

[2] Chongqing Med Univ, Chongqing Key Lab Pediat, Childrens Hosp, Chongqing, Peoples R China

[3] Peking Univ, Sch Publ Hlth, Beijing, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2022年 / 94卷 / 08期

基金：

中国国家自然科学基金;

关键词：

Age; China; Diarrhea; Enteric viruses; Rotavirus; ROTAVIRUS INFECTION; EPIDEMIOLOGY; NOROVIRUS; SURVEILLANCE; SAPOVIRUS; INFANTS;

D O I：

10.1002/jmv.27790

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Viral diarrhea is one of the leading causes of morbidity and mortality in children. This study was conducted to disclose the etiological cause and epidemiological features of viral diarrhea among children in China. From 2009 to 2021, active surveillance was performed on pediatric patients with acute diarrhea and tested for five enteric viruses. Positive detection was determined in 65.56% (3325/5072) patients and an age-specific infection pattern was observed. A significantly higher positive rate was observed in 12-23-month-old children for rotavirus (47.46%) and adenovirus (7.06%), while a significantly higher positive rate was observed for norovirus (37.62%) in 6-11-month-old patients, and for astrovirus (11.60%) and sapovirus (10.79%) in 24-47-month-old patients. A higher positive rate of rotavirus in girls and norovirus in boys was observed only among 6-11 months of patients. We also observed more norovirus among patients from rural areas in the 0-5- and 36-47-month groups and more rotavirus among those from rural areas in the 12-23-month group. Diarrhea severity was greater for rotavirus in the 6-23-month group and norovirus in the 6-11-month group. Coinfections were observed in 29.26% (973/3325) of positive patients, and were most frequently observed between rotavirus and others (89.31%). Our findings could help the prediction, prevention, and potential therapeutic approaches to viral diarrhea in children.

引用

页码：3840 / 3846

页数：7