In vitro degradation of porous PLLA/pearl powder composite scaffolds

被引：46

作者：

Liu, Y. S. ^{[1
]}

Huang, Q. L. ^{[1
]}

Kienzle, A. ^{[3
]}

Mueller, W. E. G. ^{[3
]}

Feng, Q. L. ^{[1
,2
]}

机构：

[1] Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China

[2] Tsinghua Univ, Sch Mat Sci & Engn, Minist Educ China, Key Lab Adv Mat, Beijing 100084, Peoples R China

[3] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Physiol Chem, D-55099 Mainz, Germany

来源：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2014年 / 38卷

基金：

中国国家自然科学基金;

关键词：

Degradation; PLLA; Aragonite; Vaterite; Composite scaffold; HYDROLYTIC DEGRADATION; BONE; BEHAVIOR; ACID); VIVO; FABRICATION; VATERITE;

D O I：

10.1016/j.msec.2014.02.007

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The in vitro degradation behavior of poly-L-lactide (PLLA), PLLA/aragonite pearl powder and PLLA/vaterite pearl powder scaffolds was investigated. The scaffolds were soaked in phosphate buffer solution (PBS) up to 200 days. Scanning electron microscopy (SEM), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC) were used to observe any degradation of the scaffolds. Degradation behaviors such as changes in pH, porosity, bulk density, water absorption, weight loss and mechanical properties were discussed. The results show that a gradual increase of the pH in composite scaffolds can decrease the rate of hydrolysis of PLLA. PLLA/vaterite and PLLA/aragonite scaffolds have a similar degradation behavior but a slower rate of degradation than PLLA. Crown Copyright (C) 2014 Published by Elsevier B.V. All rights reserved.

引用

页码：227 / 234

页数：8

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