E-cadherin might be a stage-dependent modulator in aggressiveness in pancreatic cancer cells

被引：1
|
作者：
Aydemir Coban, Esra [1 ]
Tecimel, Didem [1 ,2 ]
Kasikci, Ezgi [1 ,3 ]
Bayrak, Omer Faruk [1 ,2 ]
Sahin, Fikrettin [1 ]
机构：
[1] Yeditepe Univ, Engn Fac, Dept Genet & Bioengn, Istanbul, Turkey
[2] Yeditepe Univ, Yeditepe Univ Hosp, Fac Med, Dept Med Genet, Istanbul, Turkey
[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, New York, NY USA
来源：
TURKISH JOURNAL OF BIOLOGY | 2020年 / 44卷 / 05期
关键词：
Panc-1; AsPC1; E-cadherin; CRISPR/dCas9; activation; pancreas cancer; TO-MESENCHYMAL TRANSITION; ACTIVATION; JUNCTIONS;
D O I：
10.3906/biy-1912-60
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Pancreatic ductal adenocarcinoma (PDAC) pathology is known for its uncontrollable progress due to highly invasive characteristics and refractory behavior against existing chemotherapies. The aberrant expression of CDH1 (expresses the protein E-cadherin) is associated with increased overall survival in various cancers, however, E-cadherin expression in PDAC progression has remained elusive. We investigated the impact of exogenously elevated E-cadherin levels on the tumorigenicity of transduced low grade and metastatic PDAC cell lines, Panc-1 and AsPC-1, respectively. Constitutive expression of E-cadherin promoted a more hybrid E/M state in AsPC-1 cells, while it was associated with the acquisition of a more epithelial-like state in Panc1 cells. Our study suggests that E-cadherin may play differential roles in determining the metastatic characteristics of primary and metastatic pancreatic cancer cells.
引用
收藏
页码：230 / 237
页数：8
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