Click Multivalent Homogeneous Neoglycoconjugates - Synthesis and Evaluation of Their Binding Affinities

被引：36

作者：

Perez-Balderas, Francisco ^{[1
]}

Morales-Sanfrutos, Julia ^{[1
]}

Hernandez-Mateo, Fernando ^{[1
]}

Isac-Garcia, Joaquin ^{[1
]}

Santoyo-Gonzalez, Francisco ^{[1
]}

机构：

[1] Univ Granada, Fac Ciencias, Dept Quim Organ, Inst Biotecnol, E-18071 Granada, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 2009卷 / 15期

关键词：

Carbohydrates; Glycoconjugates; Multivalency; Cycloaddition; Click chemistry; Ligand design; 1,3-DIPOLAR CYCLOADDITIONS; SUPRAMOLECULAR CHEMISTRY; PHENYL GLYCOSIDES; CHEMICAL BIOLOGY; CONCANAVALIN-A; CARBOHYDRATE; AZIDES; ARRAYS; DENDRIMERS; CLUSTERS;

D O I：

10.1002/ejoc.200801170

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mannose (alpha-Man)-containing neoglycoconjugates possessing aliphatic-, aromatic-, and carbohydrate-centered architectures and differing in structural characteristics such as valency, topology, and nature of the linker have been synthesized using click chemistry that shows its value as an efficient and versatile methodology for, accessing tailor-made multivalent neoglycoconjugates. The binding behaviour of these glycomimics toward Concanavalin A (Con A) has been evaluated to determine the influence of the structural parameters. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451. Weinheim, Germany, 2009)

引用

页码：2441 / 2453

页数：13

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