Mitochondria in cancer: Not just innocent bystanders

被引：199
|
作者：
Frezza, Christian [1 ]
Gottlieb, Eyal [1 ]
机构：
[1] Beatson Inst Canc Res, Canc Res UK, Apoptosis & Tumour Metab Lab, Glasgow G61 1BD, Lanark, Scotland
来源：
SEMINARS IN CANCER BIOLOGY | 2009年 / 19卷 / 01期
关键词：
Mitochondria; Cancer; Metabolism; Glycolysis; Oxidative phosphorylation; POSITRON-EMISSION-TOMOGRAPHY; TUMOR-CELL METABOLISM; FATTY-ACID SYNTHASE; DNA MUTATIONS; COMPLEX-II; SUCCINATE-DEHYDROGENASE; GLYCOLYTIC-ENZYMES; AEROBIC GLYCOLYSIS; FUMARATE-HYDRATASE; HYPOXIA;
D O I：
10.1016/j.semcancer.2008.11.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The first half of the 20th century produced substantial breakthroughs in bioenergetics and mitochondria research. During that time, Otto Warburg observed abnormally high glycolysis and lactate production in oxygenated cancer cells, leading him to suggest that defects in mitochondrial functions are at the heart of malignant cell transformation. Warburg's hypothesis profoundly influenced the present perception of cancer metabolism, positioning what is termed aerobic glycolysis in the mainstream of clinical oncology. While some of his ideas stood the test of time, they also frequently generated misconceptions regarding the biochemical mechanisms of cell transformation. This review examines experimental evidence which supports or refutes the Warburg effect and discusses the possible advantages conferred on cancer cells by 'metabolic transformation'. (c) 2008 Elsevier Ltd. All rights reserved.
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页码：4 / 11
页数：8
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