Recent Advances in Direct C-H Bond Functionalization of Phenylalanine Derivatives

被引：5
|
作者：
Li, Xiaofang [1 ]
Xiong, Weikang [1 ]
Ding, Qiuping [1 ]
机构：
[1] Jiangxi Normal Univ, Coll Chem & Chem Engn, Key Lab Small Funct Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China
来源：
CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 39卷 / 07期
基金：
中国国家自然科学基金;
关键词：
phenylalanine; C-H functionalization; alkylation; alkenylation; arylation; REGIOSPECIFIC SYNTHESIS; NITRATION; PICOLINAMIDE; NITROARENES; ACTIVATION; AMINATION; ARYLATION; DELTA; SP(2);
D O I：
10.6023/cjoc201901029
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Phenylalanine derivatives are widely found in a broad range of pharmaceutical molecules and exhibit significant biological activity. Direct C-H bond functionalization of phenylalanine derivatives to offer an efficient approach to construct C-I, C(sp(2))-C(sp(2)), C(sp(2))-C(sp), C(sp(2))-C(sp(3)), C-N, C-B and C-O bonds is described. The transformation involves ortho-C-H bond iodination and the following intramolecular amination, ortho-alkylation, ortho-arylation, ortho-alkenylation, ortho-alkynylation, ortho-acylation, ortho-acetoxylation, ortho-amination, ortho-boronation, meta-arylation and meta-alkylation.
引用
收藏
页码：1867 / 1874
页数：8
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