Pandemic of the aging society - sporadic cerebral small vessel disease

被引：6

作者：

Lau, Alexander Yuk Lun ^{[1
,2
]}

Ip, Bonaventure Yiu Ming ^{[1
]}

Ko, Ho ^{[1
,2
,3
,4
]}

Lam, Bonnie Yin Ka ^{[1
,2
]}

Shi, Lin ^{[4
,5
]}

Ma, Karen Ka Yan ^{[1
,4
]}

Au, Lisa Wing Chi ^{[1
,2
,4
]}

Soo, Yannie Oi Yan ^{[1
]}

Leung, Thomas Wai Hong ^{[1
]}

Wong, Adrian ^{[1
,2
]}

Mok, Vincent Chung Tong ^{[1
,2
,4
,6
]}

机构：

[1] Chinese Univ Hong Kong, Fac Med, Dept Med & Therapeut, Div Neurol, Hong Kong, Peoples R China

[2] Chinese Univ Hong Kong, Fac Med, Gerald Choa Neurosci Ctr, Lui Che Woo Inst Innovat Med, Hong Kong, Peoples R China

[3] Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China

[4] Chinese Univ Hong Kong, Fac Med, Margaret Cheung KL Cheung Res Ctr Management Park, Hong Kong, Peoples R China

[5] Chinese Univ Hong Kong, Dept Imaging & Intervent Radiol, Hong Kong, Peoples R China

[6] Chinese Univ Hong Kong, Shenzhen Res Inst, Shenzhen, Guangdong, Peoples R China

来源：

CHINESE MEDICAL JOURNAL | 2021年 / 134卷 / 02期

关键词：

Cerebral small vessel disease; Clinical spectrum; Pathophysiology; WHITE-MATTER HYPERINTENSITIES; MILD COGNITIVE IMPAIRMENT; ISCHEMIC-STROKE; RISK-FACTORS; EXECUTIVE DYSFUNCTION; ALZHEIMER-DISEASE; CHINESE PATIENTS; ONSET DEMENTIA; DECLINE; ATROPHY;

D O I：

10.1097/CM9.0000000000001320

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Age-related sporadic cerebral small vessel disease (CSVD) has gained increasing attention over the past decades because of its increasing prevalence associated with an aging population. The widespread application of and advances in brain magnetic resonance imaging in recent decades have significantly increased researchers' understanding in the in vivo evolution of CSVD, its impact upon the brain, its risk factors, and the mechanisms that explain the various clinical manifestation associated with sporadic CSVD. In this review, we aimed to provide an update on the pathophysiology, risk factors, biomarkers, and the determinants and spectrum of the clinical manifestation of sporadic CSVD.

引用

页码：143 / 150

页数：8

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