Central insulin action in energy and glucose homeostasis

被引:301
|
作者
Plum, Leona
Belgardt, Bengt F.
Bruening, Jens C.
机构
[1] Univ Cologne, Dept Mouse Genet & Metab, Inst Genet, D-50674 Cologne, Germany
[2] Univ Cologne, Ctr Mol Med, D-50674 Cologne, Germany
[3] Univ Cologne, Klin & Poliklin Innere Med 2, Cologne, Germany
来源
JOURNAL OF CLINICAL INVESTIGATION | 2006年 / 116卷 / 07期
关键词
D O I
10.1172/JCI29063
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Insulin has pleiotropic biological effects in virtually all tissues. However, the relevance of insulin signaling in peripheral tissues has been studied far more extensively than its role in the brain. An evolving body of evidence indicates that in the brain, insulin is involved in multiple regulatory mechanisms including neuronal survival, learning, and memory, as well as in regulation of energy homeostasis and reproductive endocrinology. Here we review insulin's role as a central homeostatic signal with regard to energy and glucose homeostasis and discuss the mechanisms by which insulin communicates information about the body's energy status to the brain. Particular emphasis is placed on the controversial current debate about the similarities and differences between hypothalamic insulin and leptin signaling at the molecular level.
引用
收藏
页码:1761 / 1766
页数:6
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