Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome

被引：128
|
作者：
Goodarzi, Mark O.
Azziz, Ricardo
机构：
[1] Cedars Sinai Med Ctr, Dept Obstet & Gynecol, Ctr Androgen Related Disorders, Los Angeles, CA 90048 USA
[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA USA
[3] Inst Med Genet, Dept Med, Div Endocrinol Diabet & Metab, Los Angeles, CA USA
来源：
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2006年 / 20卷 / 02期
关键词：
epidemiology; polycystic ovary syndrome; phenotyping; complex disorders;
D O I：
10.1016/j.beem.2006.02.005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Polycystic ovary syndrome (PCOS) is a heterogeneous disorder, and its definition remains fluid and controversial. PCOS is characterized by clinical and/or biochemical hyperandrogenism, and is frequently accompanied by ovulatory dysfunction and polycystic ovaries. PCOS is a diagnosis of exclusion, with other androgen excess and related disorders to be excluded. The prevalence of PCOS is 6.5-8.0% of unselected women of reproductive age, using the NIH 1990 criteria. Genetically, PCOS is a common, complex disorder. Despite repeated attempts to identify the putative gene or genes responsible for this disorder, the PCOS gene(s) remain elusive.
引用
收藏
页码：193 / 205
页数：13
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