Imaging Changes in Very Young Children with Brain Tumors Treated with Proton Therapy and Chemotherapy

被引：29
|
作者：
Sabin, N. D. [1 ]
Merchant, T. E. [1 ]
Harreld, J. H. [1 ]
Patay, Z. [1 ]
Klimo, P. [2 ,5 ,6 ]
Qaddoumi, I. [3 ]
Armstrong, G. T. [4 ]
Wright, K. [3 ]
Gray, J. [1 ]
Indelicato, D. J. [7 ,8 ]
Gajjar, A. [3 ]
机构：
[1] St Jude Childrens Res Hosp, Div Diagnost Imaging, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Surg, Memphis, TN 38105 USA
[3] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA
[4] St Jude Childrens Res Hosp, Dept Epidemiol & Canc Control, Memphis, TN 38105 USA
[5] Semmes Murphey Neurol & Spine Inst, Memphis, TN USA
[6] Univ Tennessee, Ctr Hlth Sci, Dept Neurosurg, Memphis, TN 38163 USA
[7] Univ Florida, Coll Med, Dept Radiat Oncol, Gainesville, FL USA
[8] Univ Florida, Proton Therapy Inst, Jacksonville, FL USA
来源：
AMERICAN JOURNAL OF NEURORADIOLOGY | 2013年 / 34卷 / 02期
关键词：
HIGH-DOSE METHOTREXATE; NERVOUS-SYSTEM TUMORS; SKULL BASE TUMORS; RADIOTHERAPY; PSEUDOPROGRESSION; MEDULLOBLASTOMA; IRRADIATION; FEATURES; LESIONS; GLIOMA;
D O I：
10.3174/ajnr.A3219
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
PT promises to reduce side effects in children with brain tumors by sparing normal tissue compared with 3D conformal or intensity-modulated radiation therapy. Information is lacking about the combined effects of PT and chemotherapy in young children. We describe imaging changes in 8 very young children with localized brain tumors who received PT after chemotherapy. Mostly transient signal abnormalities and enhancement in brain parenchyma were observed by serial MR imaging, which were consistent with radiation-induced effects on normal-appearing tissue. Correlation with PT planning data revealed that the areas of imaging abnormality were located within or adjacent to the volume that received the highest radiation dose. Radiologists should be aware of these findings in children who receive PT after chemotherapy. In this report, we describe the time course of these PT-related imaging findings and correlate them with treatment and clinical outcomes.
引用
收藏
页码：446 / 450
页数：5
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