Triazole hybrids as new type of anti-fungal agents

The present work involves synthesis of novel anti-fungal agents containing triazole scaffold. The newly designed compounds were synthesized on the trails of ketoconazole using the molecular hybridization approach. A series of 10 compounds having (2-((1H-1,2,4-triazol-l-yl) methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl) methyl esters (4a-j) were prepared by conventional synthetic approach. The synthesized compounds were subjected for in vitro anti-fungal screening against Aspergillus niger, Aspergillus fumigatus, Candida albicans and Penicillium notatum. Out of 10 newly synthesized compounds, six compounds (4b-f and j) showed remarkable anti-fungal activity (MIC range 6.5-25 mu g/ml), whereas compound 4d (MIC 6.5 mu g/ml) was more potent than standard drug ketoconazole (MIC 12.5 mu g/ml). These triazole hybrids can be considered as potential anti-fungal agents. (C) 2013 Production and hosting by Elsevier B.V. on behalf of King Saud University.