Antidepressant Medication Prescribing Practices for Treatment of Major Depressive Disorder

Objective: The purpose of this study was to describe the prescribing practices of clinicians for patients with major depressive disorder (MDD). Methods: This population- based, descriptive study of insured patients (N= 54,107) identified people who were 18 years or older, had a claim for MDD, had at least one prescription for an antidepressantmedication in 2013, and had continuous insurance coverage during the study period. Prescription claims were evaluated to determine the most commonly prescribed antidepressant medication and most common dose. Results: The three most commonly prescribed antidepressant medicationswere citalopram (N= 11,995,22.2%), sertraline (N= 10,791, 19.9%), and trazodone (N= 9,501, 17.6%). The most common daily doseswere 20mg citalopram (N= 6,304, 52.6%), 50mg sertraline (N= 4,173, 38.7%), and 100 mg trazodone (N= 3,220, 33.9%). Conclusions: This is the first report of its kind that provides drug- and dosage- level details to demonstrate that antidepressant prescribing in clinical practice is largely within recommended guidelines.