Massive postpartum haemorrhage is a major cause of maternal and fetal morbidity and mortality. Management mainstays include transfusion therapy, uterotonic agents and surgery. The "off label" use of recombinant activated factor VII appears to have an evolving role in the management of massive postpartum haemorrhage refractory to conventional treatments. The current literature is reviewed. (c) 2006 Elsevier Ltd. All rights reserved.
机构:Univ Hosp Geneva, Dept Anaesthesiol Pharmacol & Surg Intens Care, Div Surg Intens Care, Haemostasis Unit, CH-1211 Geneva 14, Switzerland
Boehlen, F
Morales, MA
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机构:Univ Hosp Geneva, Dept Anaesthesiol Pharmacol & Surg Intens Care, Div Surg Intens Care, Haemostasis Unit, CH-1211 Geneva 14, Switzerland
Morales, MA
Fontana, P
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机构:Univ Hosp Geneva, Dept Anaesthesiol Pharmacol & Surg Intens Care, Div Surg Intens Care, Haemostasis Unit, CH-1211 Geneva 14, Switzerland
Fontana, P
Ricou, B
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机构:Univ Hosp Geneva, Dept Anaesthesiol Pharmacol & Surg Intens Care, Div Surg Intens Care, Haemostasis Unit, CH-1211 Geneva 14, Switzerland
Ricou, B
Irion, O
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机构:Univ Hosp Geneva, Dept Anaesthesiol Pharmacol & Surg Intens Care, Div Surg Intens Care, Haemostasis Unit, CH-1211 Geneva 14, Switzerland
Irion, O
de Moerloose, P
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Univ Hosp Geneva, Dept Anaesthesiol Pharmacol & Surg Intens Care, Div Surg Intens Care, Haemostasis Unit, CH-1211 Geneva 14, SwitzerlandUniv Hosp Geneva, Dept Anaesthesiol Pharmacol & Surg Intens Care, Div Surg Intens Care, Haemostasis Unit, CH-1211 Geneva 14, Switzerland
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Georgetown Univ, Med Ctr, Lombardi Comphrens Canc Ctr, Washington, DC 20007 USAGeorgetown Univ, Med Ctr, Lombardi Comphrens Canc Ctr, Washington, DC 20007 USA