EIF2A protects beta cells from ER stress by decreasing ERN1, while increasing EIF5B and global protein translation

被引:0
|
作者
Panzhinskiy, E. [1 ]
Skovso, S. [1 ]
Soukhatcheva, G. [1 ]
Taghizadeh, F. [1 ]
Dionne, D. A. [1 ]
Wildi, J. S. [1 ]
Marcil, S. [1 ]
Hu, X. [1 ]
Verchere, C. B. [1 ]
Jan, E. [1 ]
Johnson, J. D. [1 ]
机构
[1] Univ British Columbia, Vancouver, BC, Canada
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
463
引用
收藏
页码:S227 / S227
页数:1
相关论文
共 22 条
  • [1] Translation Initiation Factor eIF2A Is Upregulated by Endoplasmic Reticulum Stress and Protects Pancreatic Beta Cells from Apoptosis
    Panzhinskiy, Evgeniy
    Taghizadeh, Farnaz
    Chu, Kwan-Yi
    Hsuan, Yu
    Yang, Carol
    Jan, Eric
    Johnson, James D.
    DIABETES, 2015, 64 : A576 - A576
  • [2] The novel translation initiation factor, eIF2A, is up-regulated by endoplasmic reticulum stress and protects beta cells from apoptosis
    Panzhinskiy, E.
    Taghizadeh, F.
    Chu, K-Y.
    Yang, Y.
    Jan, E.
    Johnson, J. D.
    DIABETOLOGIA, 2014, 57 : S192 - S193
  • [3] Eukaryotic translation initiation factor 2A (eIF2A) protects pancreatic beta cells from ER stress-induced apoptosis by selective regulation of translational initiation
    Panzhinskiy, E.
    Taghizadeh, F.
    Yang, Y.
    Hu, B.
    Johnson, J. D.
    Jan, E.
    DIABETOLOGIA, 2015, 58 : S230 - S231
  • [4] FOLLICULIN TUMOR SUPPRESSOR BINDS TO TRANSLATION INITIATION FACTORS EIF2G & EIF5B AND SUPPRESSES PROTEIN SYNTHESIS
    Schneider, Meike
    Hagar, Taha
    Dinkelborg, Katja
    Bukhari, Syed I. A.
    Haferkamp, Axel
    Vasudevan, Shobha
    Iliopoulos, Othon
    JOURNAL OF UROLOGY, 2017, 197 (04): : E794 - E794
  • [5] Eukaryotic translation initiation factor 2A (eIF2A) saves pancreatic beta cells "lost in translation" during ER stress-induced apoptosis
    Panzhinskiy, E.
    Taghizadeh, F.
    Chu, K. -Y.
    Yang, Y.
    Jan, E.
    Johnson, J. D.
    DIABETOLOGIA, 2016, 59 : S218 - S218
  • [6] Remarkable conservation of translation initiation factors: IF1/eIF1A and IF2/eIF5B are universally distributed phylogenetic markers
    Sorensen, HP
    Hedegaard, J
    Sperling-Petersen, HU
    Mortensen, KK
    IUBMB LIFE, 2001, 51 (05) : 321 - 327
  • [7] Eukaryotic Initiation Factor 5B (eIF5B) Cooperates with eIF1A and eIF5 to Facilitate uORF2-Mediated Repression of ATF4 Translation
    Ross, Joseph A.
    Bressler, Kamiko R.
    Thakor, Nehal
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2018, 19 (12)
  • [8] A selective inhibitor-of eIF2α dephosphorylation protects cells from ER stress
    Boyce, M
    Bryant, KF
    Jousse, C
    Long, K
    Harding, HP
    Scheuner, D
    Kaufman, RJ
    Ma, DW
    Coen, DM
    Ron, D
    Yuan, JY
    SCIENCE, 2005, 307 (5711) : 935 - 939
  • [9] eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer
    Suresh, Shruthy
    Chen, BeiBei
    Zhu, Jingfei
    Golden, Ryan J.
    Lu, Changzheng
    Evers, Bret M.
    Novaresi, Nicole
    Smith, Bethany
    Zhan, Xiaowei
    Schmid, Vanessa
    Jun, Sojeong
    Karacz, Chelsea M.
    Peyton, Michael
    Zhong, Lin
    Wen, Zhuoyu
    Sathe, Adwait Amod
    Xing, Chao
    Behrens, Carmen
    Wistuba, Ignacio I.
    Xiao, Guanghua
    Xie, Yang
    Fu, Yang-Xin
    Minna, John D.
    Mendell, Joshua T.
    O'Donnell, Kathryn A.
    NATURE CANCER, 2020, 1 (05) : 533 - 545
  • [10] eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer
    Shruthy Suresh
    BeiBei Chen
    Jingfei Zhu
    Ryan J. Golden
    Changzheng Lu
    Bret M. Evers
    Nicole Novaresi
    Bethany Smith
    Xiaowei Zhan
    Vanessa Schmid
    Sojeong Jun
    Chelsea M. Karacz
    Michael Peyton
    Lin Zhong
    Zhuoyu Wen
    Adwait Amod Sathe
    Chao Xing
    Carmen Behrens
    Ignacio I. Wistuba
    Guanghua Xiao
    Yang Xie
    Yang-Xin Fu
    John D. Minna
    Joshua T. Mendell
    Kathryn A. O’Donnell
    Nature Cancer, 2020, 1 : 533 - 545