Inadequate Medication Side Effects in Psychiatrical Pathology

Atypical antipsychotic drugs are the first-line of therapy in adult schizophrenia but their effects in children and adolescents have not been well understood. In the current paper there is presented a case of early-onset schizophrenia (EOS) with complex prodromal symptoms for 6 months prior to the acute psychotic episode, followed by an aggravation of the condition with a suicidal attempt secondary to inadequate medication with a dopamine antagonist and a dopamine partial agonist. The patient finally responded to aripiprazole monotherapy with lack of psychiatric symptoms and improvement of social integration for over a year. In our opinion, a multidisciplinary approach involving the research of biochemical interactions between antipsychotic drugs may allow a better understanding of mental diseases, which in turn will contribute to the establishment of the most appropriate diagnostic and therapeutic scheme.