Carbazomycin G: Method Development and Total Synthesis

被引：6

作者：

Elumalai, Vijayaragavan ^{[1
]}

Gambarotti, Cristian ^{[2
]}

Bjorsvik, Hans-Rene ^{[1
]}

机构：

[1] Univ Bergen, Dept Chem, Allegaten 41, N-5007 Bergen, Norway

[2] Politecn Milan, Dept Chem Mat & Chem Engn, Piazza Leonardo da Vinci 32, I-20133 Milan, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 2018卷 / 17期

关键词：

Synthetic methods; Total synthesis; Cross-coupling; C-H activation; C-N bond formation; Redox reactions; TRANSITION-METAL-COMPLEXES; 1ST TOTAL-SYNTHESIS; ORGANIC-SYNTHESIS; DIENE COMPLEXES; BIOLOGICAL EVALUATION; SELECTIVE REDUCTION; REDUCING AGENT; ANTIBIOTICS; ALKALOIDS; EFFICIENT;

D O I：

10.1002/ejoc.201800359

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel total synthesis leading to the carbazole alkaloid carbazomycin G was designed and developed. The outlined synthetic route is composed of twelve synthetic steps including the transformations of the initial simple substrate and intermediates. To realize the designed synthesis, in total six new synthetic methods were developed and implemented to provide the target molecule in an overall yield of 8.3%.

引用

页码：1984 / 1992

页数：9

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