Trial in Progress: The Phase III, Randomized, Open-Label, Multicenter COMMODORE 1 Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Adult and Adolescent Patients with Paroxysmal Nocturnal Hemoglobinuria Currently Treated with Complement Inhibitors

被引：0
|
作者：
Risitano, Antonio
Roth, Alexander
Kulasekararaj, Austin
Pu, Jeffrey
Nishimura, Jun-Ichi
Wright, Lilyan
Appius, Anita
Sostelly, Alexandre
Sreckovic, Sasha
Vignal, Charlotte
Munir, Talha
机构：
来源：
BLOOD | 2020年 / 136卷
关键词：
D O I：
10.1182/blood-2020-137471
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页数：4
相关论文
共 50 条
  • [1] Trial in Progress: The Phase III, Randomized, Open-Label, Multicenter COMMODORE 2 Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Adult and Adolescent Patients with Paroxysmal Nocturnal Hemoglobinuria Not Previously Treated with Complement Inhibitors
    Kulasekararaj, Austin
    He, Guangsheng
    Munir, Talha
    Pu, Jeffrey
    Risitano, Antonio
    Roth, Alexander
    Sima, Camelia S.
    Appius, Anita
    Sostelly, Alexandre
    Sreckovic, Sasha
    Vignal, Charlotte
    Nishimura, Jun-Ichi
    [J]. BLOOD, 2020, 136
  • [2] The phase III, randomized, multicenter commodore 2 trial: results from the study of crovalimab vs eculizumab in paroxysmal nocturnal hemoglobinuria (PNH) patients naive to complement inhibitors
    Roeth, A.
    He, G.
    Brodsky, A.
    Chai-Adisaksopha, C.
    Dumagay, T.
    Demichelis Gomez, R.
    Hoglund, M.
    Kelly, R. J.
    Lee, J. -H
    Nishimura, J. -, I
    Obara, N.
    Risitano, A.
    Gaya, A.
    Appius, A.
    Gentile, B.
    Negricea, R.
    Zhang, Z.
    Buatois, S.
    Han, B.
    [J]. ONCOLOGY RESEARCH AND TREATMENT, 2023, 46 : 294 - 295
  • [3] Phase 3 randomized COMMODORE 1 trial: Crovalimab versus eculizumab in complement inhibitor-experienced patients with paroxysmal nocturnal hemoglobinuria
    Scheinberg, Phillip
    Cle, Diego Villa
    Kim, Jin Seok
    Nur, Erfan
    Yenerel, Mustafa N.
    Barcellini, Wilma
    Bonito, Debora
    Giai, Valentina
    Hus, Marek
    Lee, Yoojin
    Lekue, Cristina Barrenetxea
    Panse, Jens
    Ueda, Yasutaka
    Buatois, Simon
    Gentile, Brittany
    Kiialainen, Anna
    Patel, Himika
    Sreckovic, Sasha
    Uguen, Marianne
    Edwards, John
    Nagy, Zsolt
    Kulasekararaj, Austin G.
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 2024, 99 (09) : 1757 - 1767
  • [4] Phase 3 randomized COMMODORE 2 trial: Crovalimab versus eculizumab in patients with paroxysmal nocturnal hemoglobinuria naive to complement inhibition
    Roeth, Alexander
    He, Guangsheng
    Tong, Hongyan
    Lin, Zenghua
    Wang, Xiaoqin
    Chai-Adisaksopha, Chatree
    Lee, Je-Hwan
    Brodsky, Andres
    Hantaweepant, Chattree
    Dumagay, Teresita E.
    Demichelis-Gomez, Roberta
    Rojnuckarin, Ponlapat
    Sun, Jing
    Hoeglund, Martin
    Jang, Jun Ho
    Gaya, Anna
    Silva, Fernando
    Obara, Naoshi
    Kelly, Richard J.
    Beveridge, Leigh
    Buatois, Simon
    Chebon, Sammy
    Gentile, Brittany
    Lundberg, Pontus
    Sreckovic, Sasha
    Nishimura, Jun-ichi
    Risitano, Antonio
    Han, Bing
    [J]. AMERICAN JOURNAL OF HEMATOLOGY, 2024, 99 (09) : 1768 - 1777
  • [5] The phase III randomized, multicenter commodore 1 trial: comparison of crovalimab vs eculizumab in complement inhibitor-experienced patients with paroxysmal nocturnal hemoglobinuria (PNH)
    Roeth, A.
    Scheinberg, P.
    Villa Cle, D.
    Edwards, J.
    Giai, V.
    Hus, M.
    Kim, J. S.
    Barrenetxea Lekue, C.
    Nagy, Z.
    Nur, E.
    Panse, J.
    Ueda, Y.
    Yenerel, M. N.
    Appius, A.
    Balachandran, N.
    Chebon, S.
    Gentile, B.
    Buatois, S.
    Kulasekararaj, A.
    [J]. ONCOLOGY RESEARCH AND TREATMENT, 2023, 46 : 200 - 201
  • [6] Biomarker Analyses in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Crovalimab and Eculizumab: Results from the Phase III Randomized COMMODORE 2 Trial
    Lundberg, Pontus
    de la Iglesia, Silvia
    Kelly, Richard J.
    Kulasekararaj, Austin
    Nishimura, Jun-Ichi
    Risitano, Antonio M.
    Roeth, Alexander
    Buatois, Simon
    Chebon, Sammy
    Patel, Himika
    Kiialainen, Anna
    [J]. BLOOD, 2023, 142
  • [7] Safety of Crovalimab Versus Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH): Pooled Results from the Phase III COMMODORE 1, COMMODORE 2, and COMMODORE 3 Studies
    Roeth, Alexander
    Fu, Rong
    He, Guangsheng
    Alzahrani, Hazza A.
    Chou, Sheng-Chieh
    Hicheri, Yosr
    Kazmierczak, Maciej
    Recova, Viviane Lacorte
    Uchiyama, Michihiro
    Vladareanu, Ana Maria
    Beveridge, Leigh
    Buatois, Simon
    Buri, Muriel
    Shi, Dayu
    Balachandran, Nadiesh
    Srekovic, Sasha
    Scheinberg, Phillip
    [J]. BLOOD, 2023, 142
  • [8] Two Currently Recruiting Randomized Phase III Trials: COMMODORE 1 and 2 Evaluating Crovalimab Vs Eculizumab in Patients with Paroxysmal Nocturnal Hemoglobinuria with or without Current Anti-Complement Therapy
    Kulasekararaj, Austin G.
    Risitano, Antonio
    Roeth, Alexander
    He, Guangsheng
    Pu, Jeffrey
    Wright, Lilyan
    Appius, Anita
    Sostelly, Alexandre
    Sreckovic, Sasha
    Stanzel, Sven F.
    Munir, Talha
    Nishimura, Jun-Ichi
    [J]. BLOOD, 2021, 138
  • [9] The efficacy and safety of eculizumab biosimilar in patients with paroxysmal nocturnal hemoglobinuria. Results of a phase III randomized open-label comparative clinical trial
    Kulagin, Aleksandr D.
    Bakirov, Bulat A.
    Davydkin, Igor L.
    Elykomov, Ilya, V
    Konstantinova, Tatiana S.
    Korobkin, Aleksandr, V
    Kosinova, Marina, V
    Mazurov, Vadim, I
    Minaeva, Natalia, V
    Proidakov, Andrei, V
    Ptushkin, Vadim V.
    Shatokhin, Yuri, V
    Lin'kova, Yulia N.
    Zinkina-Orikhan, Arina, V
    Morozova, Maria A.
    [J]. TERAPEVTICHESKII ARKHIV, 2021, 93 (11): : 1340 - 1348
  • [10] Patient-Reported Outcomes (PROs) in Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Treated with Crovalimab and Eculizumab: Results from the Phase III Randomized COMMODORE 2 and COMMODORE 1 Trials
    Panse, Jens
    Cermak, Jaroslav
    Kyselova, Olena
    Gotoh, Akihiko
    Sahin, Fahri
    Schrezenmeier, Hubert
    Chang, Alice C.
    Gentile, Brittany
    Uguen, Marianne
    Han, Bing
    [J]. BLOOD, 2023, 142
12345