Oxidative metabolism as a novel therapeutic target to eradicate T-ALL with mitochondrial complex I inhibitor IACS-010759

被引：0

作者：

Baran, Natalia ^{[1
]}

Lodi, Alessia ^{[2
]}

Sweeney, Shannon ^{[2
]}

Kuruvilla, Vinitha Mary ^{[1
]}

Cavazos, Antonio ^{[1
]}

Skwarska, Anna ^{[3
]}

Velandy, Sriram Shanmuga ^{[1
]}

Harutyunyan, Karine ^{[1
]}

Feng, Ningping ^{[1
]}

Gay, Jason ^{[1
]}

Kaminski, Marcin ^{[4
]}

Jabbour, Elias J. ^{[1
]}

Ferrando, Adolfo ^{[5
]}

Di Francesco, M. Emilia ^{[1
]}

Marszalek, Joseph R. ^{[1
]}

Tiziani, Stefano ^{[2
]}

Konopleva, Marina ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[2] Univ Texas Austin, Austin, TX 78712 USA

[3] Gdansk Univ Technol, Gdansk, Poland

[4] St Jude Childrens Res Hosp, 332 N Lauderdale St, Memphis, TN 38105 USA

[5] Columbia Univ, New York, NY USA

来源：

CANCER RESEARCH | 2018年 / 78卷 / 13期

关键词：

D O I：

10.1158/1538-7445.AM2018-1875

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1875

引用

页数：2

共 24 条

[1] Targeting the Mitochondria Metabolism of T-ALL with Novel Mitochondrial Complex I Inhibitor IACS-010759
Baran, Natalia
Lodi, Alessia
Sweeney, Shannon
Kuruvilla, Vinitha Mary
Cavazos, Antonio
Velandy, Sriram Shanmuga
Harutyunyan, Karine
Feng, Ningping
Gay, Jason
Kaminski, Marcin
Jabbour, Elias J.
Ferrando, Adolfo
Di Francesco, M. Emilia
Tiziani, Stefano
Marszalek, Joseph R.
Konopleval, Marina
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2017, 17 (10): : S1 - S2
[2] Mitochondrial Complex I Inhibition with Iacs-010759 in T-ALL Preclinical Models
Baran, Natalia
Molina, Jennifer
Cavazos, Antonio
Harutyunyan, Karine
Feng, Ningping
Gay, Jason
Piya, Sujan
Velandy, Sriram Shanmuga
Jabbour, Elias J.
Andreeff, Michael
Tiziani, Stefano
Ferrando, Adolfo A.
Zweidler-McKay, Patrick
Di Francesco, M. Emilia
Marszalek, Joseph R.
Konopleva, Marina
BLOOD, 2016, 128 (22)
[3] IACS-010759, a novel inhibitor of complex I in Phase I clinical development to target OXPHOS dependent tumors
Molina, Jennifer
Bandi, Madhavi
Bardenhagen, Jennifer
Bristow, Christopher
Carroll, Christopher
Chang, Edward
Cross, Jason
Daver, Naval
Feng, Ningping
Gay, Jason
Do, Mary Geck
Greer, Jennifer
Han, Jing
Hirst, Judy
Huang, Sha
Jiang, Yongying
Kang, Zhijun
Konopleva, Marina
Liu, Gang
Ma, Helen
Matre, Polina
McAfoos, Timothy
Meric-Bernstam, Funda
Morlacchi, Pietro
Muller, Florian
Protopopova, Marina
Smith, Melinda
Sonal, Sonal
Sun, Yuting
Theroff, Jay
Viale, Andrea
Xu, Quanyun
Toniatti, Carlo
Draetta, Giulio
Jones, Philip
Di Francesco, M. Emilia
Marszalek, Joseph R.
CANCER RESEARCH, 2017, 77
[4] Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and Glutaminase Inhibition
Baran, Natalia
Lodi, Alessia
Sweeney, Shannon Renee
Renu, Pandey
Kuruvilla, Vinitha Mary
Cavazos, Antonio
Herranz, Daniel
Skwarska, Anna
Warmoes, Marc
Davis, R. Eric
Harutyunyan, Karine
Feng, Ningping
Gay, Jason P.
Konoplev, Sergej Naumovich
Kaminski, Marcin
Kovacs, Jeffrey J.
Du, Di
Jabbour, Elias J.
Ferrando, Adolfo A.
Di Francesco, Maria E.
Lorenzi, Philip L.
Marszalek, Joseph R.
Tiziani, Stefano
Konopleva, Marina Y.
BLOOD, 2018, 132
[5] Novel Complex I inhibitor IACS-010759 Targets Leukemia Initiating Cells (LICs) in AML Patients
Baran, Natalia
Han, Lina
Herbrich, Shelley
Sweeney, Shannon Renee
Lodi, Alessia
Gay, Jason
Feng, Ningping
Molina, Jennifer R.
Kaminski, Marcin
Guzman, Monica L.
Al-Atrash, Gheath
Tiziani, Stefano
Marszalek, Joseph R.
Konopleva, Marina
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2017, 17 : S297 - S297
[6] Targeting cancer and immune cell metabolism with the complex I inhibitors metformin and IACS-010759
Pujalte-Martin, Marc
Belaid, Amine
Bost, Simon
Kahi, Michel
Peraldi, Pascal
Rouleau, Matthieu
Mazure, Nathalie M.
Bost, Frederic
MOLECULAR ONCOLOGY, 2024, 18 (07) : 1719 - 1738
[7] Novel Oxidative Phosphorylation Inhibitor IACS-010759 Induces AMPK-Dependent Apoptosis of AML Cells
Yang, Haeun
Tabe, Yoko
Sekihara, Kazumasa
Saito, Kaori
Ma, Helen
Ruvolo, Vivian
Imoto, Junichi
Ikeo, Kazuho
Mogushi, Kaoru
Hosoya, Masaki
Hayashizaki, Yoshihide
Yamanaka, Yasunari
Miida, Takashi
Andreeff, Michael
Marszalek, Joseph R.
Konopleva, Marina
BLOOD, 2017, 130
[8] Phase I trial of IACS-010759 (IACS), a potent, selective inhibitor of complex I of the mitochondrial electron transport chain, in patients (pts) with advanced solid tumors.
Yap, Timothy A.
Ahnert, Jordi Rodon
Piha-Paul, Sarina Anne
Fu, Siqing
Janku, Filip
Karp, Daniel D.
Naing, Aung
Dumbrava, Ecaterina Elena Ileana
Pant, Shubham
Subbiah, Vivek
Tsimberidou, Apostolia Maria
Hong, David S.
Rose, Kelsey Meagan
Xu, Quanyun
Vellano, Christopher P.
Mahendra, Mikhila
Jones, Philip
Di Francesco, Maria Emilia
Marszalek, Joseph R.
Meric-Bernstam, Funda
JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
[9] Discovery and development of IACS-010759, a novel inhibitor of Complex I currently in phase I studies to exploit oxidative phosphorylation dependency in acute myeloid leukemia and solid tumors
Di Francesco, Maria Emilia
Marszalek, Joseph R.
McAfoos, Timothy
Carroll, Christopher L.
Kang, Zhijun
Liu, Gang
Theroff, Jay P.
Bardenhager, Jennifer P.
Bandi, Madhavi L.
Molina, Jennifer R.
Gera, Sonal
Protopopova, Marina
Sun, Yuting
Do, Mary K. Geck
Feng, Ningping
Gay, Jason P.
Muller, Florian
Konopleva, Marina
Meric-Bernstam, Funda
Toniatti, Carlo
Heffernan, Timothy P.
Draetta, Giulio F.
Jones, Philip
CANCER RESEARCH, 2018, 78 (13)
[10] IACS-010759, a potent inhibitor of glycolysis-deficient hypoxic tumor cells, inhibits mitochondrial respiratory complex I through a unique mechanism
Tsuji, Atsuhito
Akao, Takumi
Masuya, Takahiro
Murai, Masatoshi
Miyoshi, Hideto
JOURNAL OF BIOLOGICAL CHEMISTRY, 2020, 295 (21) : 7481 - 7491

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