Nitric oxide (NO) inhibits 2 IFN gamma-induced genes: (1) Class II-MHC (1a) by inhibiting increased abundance of class II transactivator (CIITA) mRNA, & (2) Fc gamma RI by inhibiting the activation of the IFN gamma activated sequence (GAS) in the promoter.

被引：0

作者：

Sicher, SC ^{[1
]}

Penfield, JG ^{[1
]}

Chung, GW ^{[1
]}

Lu, CY ^{[1
]}

机构：

[1] UNIV TEXAS, SW MED CTR, DALLAS, TX USA

来源：

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY | 1996年 / 7卷 / 09期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：A3241 / A3241

页数：1

共 7 条

[1] Stat1 alpha expression is involved in IFN-gamma induction of the class II transactivator and class II MHC genes
Lee, YJ
Benveniste, EN
JOURNAL OF IMMUNOLOGY, 1996, 157 (04): : 1559 - 1568
[2] Nitric Oxide Inhibits INFγ-induced Increases in CIITA mRNA Abundance and Activation of CIITA Dependent Genes—Class II MHC, Ii and H-2M
Mariusz L. Kielar
Stanley C. Sicher
Jeffery G. Penfield
D. Rohan Jeyarajah
Christopher Y. Lu
Inflammation, 2000, 24 : 431 - 445
[3] Nitric oxide inhibits INFγ-induced increases in CIITA mRNA abundance and activation of CIITA dependent genes -: Class II MHC, Ii and H-2M
Kielar, ML
Sicher, SC
Penfield, JG
Jeyarajah, DR
Lu, CY
INFLAMMATION, 2000, 24 (05) : 431 - 445
[4] AUGMENTATION OR INHIBITION OF IFN-GAMMA-INDUCED MHC CLASS-II EXPRESSION BY LIPOPOLYSACCHARIDES - THE ROLES OF TNF-ALPHA AND NITRIC-OXIDE, AND THE IMPORTANCE OF THE SEQUENCE OF SIGNALING
SICHER, SC
CHUNG, GW
VAZQUEZ, MA
LU, CY
JOURNAL OF IMMUNOLOGY, 1995, 155 (12): : 5826 - 5834
[5] RB AND A NOVEL E2F-1 BINDING-PROTEIN IN MHC CLASS-II DEFICIENT B-CELL LINES AND NORMAL IFN-GAMMA INDUCTION OF THE CLASS-II TRANSACTIVATOR CIITA IN CLASS-II NONINDUCIBLE RB-DEFECTIVE TUMOR LINES
TSCHICKARDT, ME
LU, YM
JACIM, M
USSERY, GDW
STEIMLE, V
MACH, B
BLANCK, G
INTERNATIONAL JOURNAL OF CANCER, 1995, 62 (04) : 461 - 465
[6] TGF-BETA SUPPRESSION OF IFN-GAMMA-INDUCED CLASS-II MHC GENE-EXPRESSION DOES NOT INVOLVE INHIBITION OF PHOSPHORYLATION OF JAK1, JAK2, OR SIGNAL TRANSDUCERS AND ACTIVATORS OF TRANSCRIPTION, OR MODIFICATION OF IFN-GAMMA ENHANCED FACTOR-X EXPRESSION
PANEK, RB
LEE, YJ
BENVENISTE, EN
JOURNAL OF IMMUNOLOGY, 1995, 154 (02): : 610 - 619
[7] IFN-gamma and LPS differentially modulate class II MHC and B7-1 expression on primary murine renal tubular epithelial cells. Effects on nephritogenic CD4(+) TH2 cell activation.
Banu, N
Meyers, CM
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1997, 8 : A2100 - A2100

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