Chiral Primary Amine/Palladium Dual Catalysis for Asymmetric Allylic Alkylation of β-Ketocarbonyl Compounds with Allylic Alcohols

被引：93

作者：

Zhou, Han ^{[1
]}

Zhang, Long ^{[1
]}

Xu, Changming ^{[1
]}

Luo, Sanzhong ^{[1
]}

机构：

[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 43期

关键词：

allylic alcohols; asymmetric allylic alkylation; chiral primary amines; palladium; beta-ketocarbonyl compounds; TRANSITION-METAL; ENAMINE CATALYSIS; ALPHA-ALLYLATION; PHOSPHORIC-ACID; BOND-CLEAVAGE; PALLADIUM; ALDEHYDES; LIGANDS; COMBINATION; ACTIVATION;

D O I：

10.1002/anie.201505946

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient dual catalytic system composed of a chiral primary amine and a palladium complex was developed to promote the direct asymmetric allylic alkylation (AAA) of beta-ketocarbonyl compounds. In particular, the synergistic dual catalytic system enabled the AAA reaction of challenging acyclic aliphatic ketones, such as b-ketocarbonyl compounds and 1,3-diketones.

引用

页码：12645 / 12648

页数：4

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