Breast Cancer: Major Risk Factors and Recent Developments in Treatment

被引：115

作者：

Majeed, Wafa ^{[1
]}

Aslam, Bilal ^{[1
]}

Javed, Ijaz ^{[1
]}

Khaliq, Tanweer ^{[1
]}

Muhammad, Faqir ^{[1
]}

Ali, Asghar ^{[1
]}

Raza, Ahmad ^{[1
]}

机构：

[1] Univ Agr Faisalabad, Dept Physiol & Pharmacol, Faisalabad, Pakistan

来源：

ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2014年 / 15卷 / 08期

关键词：

Cancer; breast cancer; leptin; BRCA1; BRCA2; antibodies; enzyme inhibitors; POSTMENOPAUSAL WOMEN; TAMOXIFEN; ANASTROZOLE; FULVESTRANT; METAANALYSIS; DOXORUBICIN; INHIBITION; STRATEGIES; LETROZOLE; APOPTOSIS;

D O I：

10.7314/APJCP.2014.15.8.3353

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Breast cancer is the most common in women worldwide, with some 5-10% of all cases due to inherited mutations of BRCA1 and BRCA2 genes. Obesity, hormone therapy and use of alcohol are possible causes and over-expression of leptin in adipose tissue may also play a role. Normally surgery, radiation therapy and chemotherapy allow a good prognosis where screening measures are in place. New hope in treatment measures include adjuvant therapy, neoadjuvant therapy, and introduction of mono-clonal antibodies and enzyme inhibitors.

引用

页码：3353 / 3358

页数：6

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